Hailu, Serkalem (2016) Serum Total and Placental Alkaline Phosphatas at Second and Third Trimesters of Normal Pregnant Mothers from July to Nov 2015 at Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Alkaline phosphatase (ALP) (EC 3.1.3.1.) is an enzyme which catalyzes the hydrolysis of phosphate esters at an alkaline PH. Placental alkaline phosphatase isoenzyme (PLAP) has several vital roles during pregnancy for supporting fatal growth and development. The change of PLAP may be associated with high blood pressure, preterm delivery and other complication. It could be an indicator of overall placental performance and pregnancy outcomes. Therefore, there is the need to determine and proper interpretation in our local setup. Objectives: To evaluate serum total and placental alkaline phosphatase at second and third trimesters in normal pregnant mothers in our local setup. Method: Across-sectional study was done on randomly selected 333 consenting apparently healthy pregnant mothers at Zewditu Memorial Hospital in Addis Ababa, Ethiopia. Maternal demographic characteristic was obtained through questionnaires and medical chart review. The TALP and PLAP were analyzed by Human 4-Nitrophenylphosphatas (4-NPP) substrate. The data was analyzed using the SPSS software, version 21. The data was assessed using nonparametric analysis; hence the data was found to be skewed. P< 0.05 was considered statistically significant. Result: The median of TALP and PLAP in second trimester were ( 163 IU/L) and (25 IU/L) respectively while in third trimester were (334 IU/L) and (141IU/L) respectively and at term were (449 IU/L) and ( 230 IU/L) respectively (P< 0001). Strong positive correlation observed between TALP (r2 = 0.805, p<0.001) and PALP with gestational age (r2 = 0.805, P< 0.001). Chisquare showed positive association with blood group and blood pressure (P<0.05). Conclusion and Recommendation There was significant increasing serum TALP and PLAP with advancing gestational age. There was a peak levels at term. Strong positive correlation observed between TALP and PALP with gestational age. Also, blood group and blood pressure were significantly associated. Thus, it could be used as an easy accessible and affordable biomarker for monitoring the status of pregnancy.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Total and Placental alkaline phospatase, pregnant mothers Trimester |
| Subjects: | Q Science > QD Chemistry R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 29 Nov 2018 10:30 |
| Last Modified: | 29 Nov 2018 10:30 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7986 |
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