Kirba, Sisay (2014) Seroprevalence of HBsAg among Pregnant Woman and Rate of Vertical Transmission in 3 Teaching Hospitals in Addis Ababa. Other thesis, Addis Ababa University.
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Abstract
BACKGROUND HBV and HIV are the two most important viral infectious agents which share common modes of transmission and which can seriously affect the health of both the pregnant women and her baby. Vertical transmission of HBV from the mother to her baby is the most important modes of transmission in Africa. Neonates who contract the virus from their mother have more than 90% chance of becoming chronic carriers and this can be prevented by vaccinating the baby immediately after delivery.There are only few studies on the prevalence and rate of vertical transmission of HBV during pregnancy in Addis Ababa. OBJECTIVE To determine the seroprevalence of HBsAg during pregnancy and its rate of vertical transmission. METHODS A cross sectional study was conducted from May to September 2014 in three teaching hospitals in Addis Ababa. A total of 530 pregnant women were included in the study. Sociodemogrhaphic factors and explanatory variables were collected with structured questionnaire. HBsAg were tested with ELISA and HIV was tested by Rapid test kits following national HIV test algorithms. The mothers with HBsAg positivity were also tested for HBeAgand followed till they deliver and cord blood was tested for HBsAg with ELISA. RESULTS 24/530(4.5%) were tested positive for HBsAg and of these 2(8.3%) were also positive for HBeAg. Of mothers with HBsAg 4(16.7%) were also positive for HIV. 17/530(3.2%) were tested positive of HIV and 4(23.5%) were also positive for HBsAg. Being single pregnant women (AOR=6,95CI,1.5-22.8) and having HIV (AOR=5.6,95CI,1.4-22.1) has statistically significant relationship with Positivity for HBsAg. Having HBsAg was the only variable associated with having HIV (AOR=6, 95CI, 1.7-21.5). All cord blood tested for HBsAg were negative. CONCLUSSIONS The prevalence of HBV among pregnant mothers in Addis ababa is of intermediate endemicity. The prevalence of HIV among pregnant women of Addis ababa is 3.2% and 16.6% of those mothers with HBV also has HIV.Single pregnant women and those pregnant women with HIVwere more likely to test positive for HBsAg.There was no perinatal transmission in this study and the perinatal outcome of pregnant women with HBsAg seems to be not adversely affected.
| Item Type: | Thesis (Other) |
|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 10 Aug 2018 09:03 |
| Last Modified: | 10 Aug 2018 09:03 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/8036 |
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