Ayalew, Sosina (2014) Bacterial Profile and Drug Resistance Pattern of Pathogens Isolated from Wound Infection at Armed Force Referral and Teaching Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Introduction: - Wound infections are associated with increased morbidity and mortality. Etiologic agents of wound infections vary with geographical locations. Pathogens that infect wounds can be part of normal flora or acquired from the hospital environment. Objectives: The aim of this study was to investigate the profile of pathogens cultured from infected wound and determine their antimicrobial resistance pattern to commonly prescribed antibiotics. Methods: prospective cross sectional study was conducted at ARFTH from December 2013 to May 2014. Swabs from different types of wounds were processed to investigate etiologic agents using standard microbiological technique. Antimicrobial susceptibility tests were done using disc diffusion technique as per the standard modified Kirby-Bauer method. Result Out of 300 wound swab samples analyzed, 205(68.3%) were culture positive. 33 (16.1%) of the culture had double infections. and total 238 bacteria were isolated from 205 cases.. Staphylococcus aureus was the most frequently isolated pathogen which accounted for 91 (38.2%) of isolates followed by Pseudomonas aeroginesa 53 (22.3%). The sensitivity rates of norfloxacin, gentamicin and ceftriaxone were 82.8%, 78.9%, and 76.9% respectively. The overall MDR (resistant to three or more antibiotics) rate of gram positive bacteria were 73.6% and 67.6% of the gram negative bacterial isolates were identified as multiple drug resistants. Conclusion S. aureus and psuedomonas aeroginesa were the predominant causes of wound infections. norfloxacin Gentamicin and ceftraxone were the most effective drugs. Periodic surveillance of the species of bacteria involved in wound infection and determination of their antimicrobial resistance is recommended for empirical treatment.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | wound infection, bacterial profile, drug resistance pattern |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 25 Jul 2018 09:51 |
| Last Modified: | 25 Jul 2018 09:51 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/8073 |
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