Lega, Tebarek (2015) Bacterial Uropathogens and their Drug Resistance Pattern in Diabetic Patients Attending Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Urinary tract infection (UTI) is one of the most common infections encountered and treated worldwide. UTI has been reported to be around four times higher in diabetics compared to non-diabetic patients. Since diabetic patients are at a high risk of development of UTIs, it is recommended that special attention is paid to them, especially for the management of bacterial UTIs. Objective: The aim of this study was to determine prevalence of significant bacteriuria and assess drug susceptibility pattern of the bacterial isolates in diabetic patients. Materials and Methods: A cross sectional study was conducted in Yekatit 12 Hospital Medical College from April to July 2015. . In this study, 246 patients diagnosed with diabetes mellitus were recruited consecutively. A standard questionnaire was used to collect information regarding the socio-demographic status and clinical history of the study participants. Mid-stream urine was used for chemical analysis, microscopy and microbiological isolation and identification of bacteria. Standardized disc diffusion method was used for the determination of antibiotic sensitivity testing. Data were entered into and analyzed by SPSS version 20. Results: Among the 246 study participants, 150 (60%) of them were females and 96 (40%) were males. The mean age of the study population was 51.5 years. Pyuria was detected in 27 (11%) of the urine specimens examined microscopically. Of the 246 urine specimens cultured on CLED and blood agar plate, 17(6.9%) of them showed significant bacteriuria. Among the 17 bacterial isolates, E. coli was the most frequently isolated one, accounting 10 (53%), followed by Klebsiella species 4 (21%). All the isolates showed 100% sensitivity to nitrofurantoin, except Proteus species, which exhibited resistance to the antibiotic. The multidrug resistant rate of the isolates in our study was 31.6% Conclusion and Recommendation: The overall prevalence of significant bacteriuria in our study was 6.9%. Even though Proteus species showed resistance to nitrofurantoin, all the remaining isolates were 100% sensitive to the antimicrobial. Use of antibiotics for treating UTI in DM patients should be supported with periodic culture and drug susceptibility test studies in a given geographical location.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 03 Aug 2018 12:19 |
| Last Modified: | 03 Aug 2018 12:19 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/8143 |
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