Performance Evaluation of Cell-Dyn 1800 and Sysmex KX-21 Hematology Analyzers at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Adinew, Tibebe (2015) Performance Evaluation of Cell-Dyn 1800 and Sysmex KX-21 Hematology Analyzers at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.

PDF (Performance Evaluation of Cell-Dyn 1800 and Sysmex KX-21 Hematology Analyzers at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia) Tibebe Adinew.pdf - Accepted Version Restricted to Repository staff only Download (1MB) | Request a copy

Abstract

Background: To assure the accuracy of results and performance of hematology analyzers, each laboratory must evaluate their performance. Different models of Sysmex and Cell- Dyn analyzers are commonly used in Ethiopia including St’ Paul’s Hospital Millennium Medical College. However, their performance has not been evaluated in most cases. If hematology analyzers are not verified and evaluated for the specific population they serve the diagnosis of many of diseases and hematology related clinical disorders will be unreliable. Objective: To evaluate the performance specifications of Cell-Dyn 1800 and Sysmex KX-21 that are found in St. Paul’s Hospital Millennium Medical College. Methods: A hospital based cross-sectional study with purposive sampling technique was used at St. Paul’s Hospital Millennium Medical College from April 1 to April 8; 2015. A sample of normal values was used for repeatability, high target values of hemoglobin, RBC, WBC and platelets for linearity and carryover checks with subsequent background count were used. Data were collected using observation checklist and then entry, cleaning and analysis were performed by Microsoft Excel 2007 and SPSS version 20. Percentage, %CV, residual plotting, and Pearson´s correlation coefficient were used to describe the results. Result: precision check revealed that both Sysmex KX-21 and Cell-Dyn 1800 values fall within the manufacturers’ specifications. Linearity verifications of WBC, Hemoglobin, RBC and Platelet showed that both analyzers produced a very good correlation coefficient of > 0.97, which is also confirmed by residual plotting where all the values of the diluted samples surpassed the manufacturers’ specifications. As to carryover both analyzers showed an excellent carryover percentage of <1% which surpassed the manufacturers’ specifications. Conclusion: Sysmex KX-21 and Cell-Dyn 1800 met the manufacturer’s specifications for precision, linearity and carryover.

Item Type:	Thesis (Masters)
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Africana
Depositing User:	Emmanuel Ndorimana
Date Deposited:	02 Aug 2018 08:49
Last Modified:	02 Aug 2018 08:49
URI:	http://thesisbank.jhia.ac.ke/id/eprint/8272

Actions (login required)

View Item