Mamo, Tizalegn Tesfaye (2016) Comparison of One Day-Dose Versus Multiple Day Antibiotic Prophylaxis in Preventing Post Cesarean Section Infection: A Non-Inferiority Prospective Cohort Study, 2015/16. Masters thesis, Addis Ababa University.
![[img]](http://thesisbank.jhia.ac.ke/style/images/fileicons/application_pdf.png) |
PDF (Comparison of One Day-Dose versus Multiple Day Antibiotic Prophylaxis in Preventing Post Cesarean Section Infection: A Non-Inferiority Prospective Cohort Study, 2015/16)
TIZALEGN TESFAYE MAMO.pdf - Accepted Version Restricted to Repository staff only Download (589kB) | Request a copy |
Abstract
Background: According to the Center for Disease Control and prevention, surgical site infections are classified as being incisional and organ space that must develop within 30 days of operation. Objective: The objective of this research was to assess the effectiveness of taking 1day against 7 days antibiotic prophylaxis on maternal infection after cesarean section Methodology: A prospective follow up study was conducted in which 209 women were grouped into exposed and non-exposed arms based on PO antibiotics given on discharge date. Each patient was observed in the post-operative ward and was followed back to home till 30 days from the operation day. Four hourly temperatures was taken as long as they stay in the hospital. Fever developing or persisting for 48 hours of >37oc after surgery was included as the febrile morbidity. Wound was examined on 3rd, 7th, 14th, 21st.and 30 rd. Comparisons between groups was obtained by x2 test. Stratified analyses, survival analysis and Cox regression was used to identify risk factors for infection. Results were reported with 95% confidence interval (CI). Result: in the 7 day antibiotics group 51 mothers (50%) had ruptured membranes compared with 40 (37.4%) in the 1 day antibiotics group but it was not significant at 5% level of significance (p = 0.06). The mean duration of operation room stay was 34.50 ± 6.265 minutes in the exposed group and 35.14 ± 5.89 minutes in an unexposed group (p = 0.30). During the study period, a total of 30 mothers (14.3%) infected giving an infection incidence rate of 5.1 per 1000 persondays, 179 (85.6%) were censored well, while total of 8 (3.8%) were lost to follow up. For 7 days prophylactic groups, 14 infection (13.2%) were reported, giving an overall infection rate of 4 per 1000 person-days, while in a 1 day prophylactic antibiotics group 16 (15.5%) infection were reported giving a incidence rate of 5 per 1000 person-days(P<0.8). In conclusion, our study showed that there was no significant difference between the two groups in terms of single day doses versus multiple day’s doses of antibiotic prophylaxis against postoperative infection in emergency caesarean section. So I recommend physicians to prescribe 1 day regimen prophylactic antibiotics.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RT Nursing |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 02 Aug 2018 08:01 |
| Last Modified: | 02 Aug 2018 08:01 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/8376 |
Actions (login required)
 |
View Item |