Comparative Clinical Features of Trypanosoma Isolates in Goats and Assessment of Diminazine Aceturate and IsometamediumChloride Treatment

Tsegaye, Abrham Ayele and Nigatu, Shimelis Dagnachew and Tarekegn, Zewdu Seyoum (2017) Comparative Clinical Features of Trypanosoma Isolates in Goats and Assessment of Diminazine Aceturate and IsometamediumChloride Treatment. Masters thesis, University of Gondar.

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Abstract

Introduction: Trypanosoma congolense is very pathogenic trypanosome species infecting livestock. Isoenzymatic differences in different T. congolense isolates resulted in a subdivision of the T. congolense species in to several types with different pathogenicity. However, there is no study showing if T. congolense strains are different in Ethiopia. Objectives: Thus the objective of this study was to characterize and compare the clinically visible pathological features and drug resistance patterns of two T. congolense isolates from two tsetse infested areas of northwest Ethiopia. Methods: A total of 35 trypanosome free goats were randomly assigned in to 7 experimental groups each of which containing five replicas (goats): Each experimental animal except the Group 7) was inoculated with 2 ml of parasitaemic blood at a parasitaemia level of 1×106 parasites/ml of blood. Result: Trypanosomiasis was detected on day 5 and day 6 of post infection (Pi) in Jabitehenan and Jawi, T. congolense isolates infected groups respectively. Trypanocidal treatment was given on day 14 of post infection when peak parasitaemia was detected. 7mg/kg for Group 2 and Group 5and 1mg/kg for Group 3 and Group 6 were the treatment doses for DA and ISM respectively. All of the infected control groups were get severe clinical signs and recumbence within 27 59 days of post infection. The mean PCV, total RBC and Hgb concentration values of Jabitehenan isolate infected groups were significantly (P<0.05) lower than Jawi isolate infected groups and severe clinical signs in group 4 were occurred earlier than group 1. Conclusion: These finding gives clues for the presence of inter isolate T. congolense difference. Neither of the DA nor ISM treatment groups attained complete recovery. further molecular based study is essential to confirm inter isolate differences. Keywords: Clinical features Drug resistance, Diminazene Aceturate, Isometamidium Chloride, Goats, Trypanosoma congolense, Northwest Ethiopia

Item Type:	Thesis (Masters)
Additional Information:	T. congolense isolates from Jabitehenan and T. congolense isolates from Jawi were shown to have inter-isolate variation, according to the findings.
Uncontrolled Keywords:	Clinical features Drug resistance, Diminazene Aceturate, Isometamidium Chloride, Goats, Trypanosoma congolense, Northwest Ethiopia
Subjects:	Q Science > QL Zoology S Agriculture > SF Animal culture
Divisions:	Africana
Depositing User:	Dr. Abrham Ayele Tsegaye
Date Deposited:	08 Feb 2022 07:47
Last Modified:	08 Feb 2022 07:47
URI:	http://thesisbank.jhia.ac.ke/id/eprint/9691

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