The Prevalence of Chlamydiae in Late Onset Neonatal Pneumonia in the Newborn Unit Kenyatta National Hospital

Govedi, Dr. Fridah Afandi (2001) The Prevalence of Chlamydiae in Late Onset Neonatal Pneumonia in the Newborn Unit Kenyatta National Hospital. Masters thesis, University of Nairobi.

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Abstract

Fifty-two neonates who presented with late onset pneumonia were sequentially recruited for this study, whose study objective was:- to determine the prevalence of Chlamydiae colonization of the upper respiratory tract in neonates at Kenyatta National Hospital and to estimate the proportion of late onset neonatal pneumonia that may be associated with Chlamydiae in these neonates. Chest radiographs were used to describe interstitial pneumonitis and Chlamydiae antigen detection in nasopharyngeal aspirates by direct immunofluorescence technique was conducted in all these neonates.Probable contributory factors to Chlamydiae colonization and probable causation of atypical pneumonia such as mode of delivery, birth weight, and gestation were also evaluated.Thirty-three patients had Chlamydiae isolated in their nasopharygeal aspirates. This gave a colonization rate of 63.5%. Twenty-four out of forty-seven patients had a combination of Chlamydiae colonization and radiological evidence of interstitial pneumonitis. This fulfilled the case definition of atypical pneumonia. This gave a prevalence of atypical pneumonia of 51%.The positive predictive value of chest radiographs alone for diagnosis of atypical pneumonia was 0.73 with a sensitivity of 80% and specificity of 50%.Atypical pneumonia did not have any association with mode of delivery, maturity, birth weight, sex, and postnatal age. Conclusion It was concluded that there is a high carrier rate of Chlamydiae often associated with actual pneumonia in our centre. As mode of delivery did not alter this carriage rates, nosocomial sources were speculated.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions:	Africana
Depositing User:	Geoffrey Obatsa
Date Deposited:	05 Aug 2016 11:48
Last Modified:	05 Aug 2016 13:20
URI:	http://thesisbank.jhia.ac.ke/id/eprint/982

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