Abayneh, Elias (2014) The Effect of Psidium Guava Leaf Extract on Blood Pressure in Guinea Pigs, and Weight, Lipid Profiles and Serum Liver Enzymes in Fructose Fed Swiss Albino Mice. Masters thesis, Addis Ababa University.
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Abstract
Background: Hypertension is an elevation of arterial blood pressure greater than normal. HTN affects 1 billion people globally and accounts for approximately 7.1 million deaths annually. Dyslipidemia is abnormal lipid accumulation in the body due to either defect in lipid metabolism or clearance. It is highly prevalent worldwide including in Ethiopia, where it affects especially urban populations. Hypertension and dyslipidemia are highly correlated and they are significant risk factors for cardiovascular disorders. Some medicinal plants are used in traditional medicine for the treatments hypertension and dyslipidemia. Psidium guava (P. guava) is one medicinal plant which is widely cultivated and popularly used in traditional medicine treatment of diseases such as diabetes, vomiting, diarrhea and dyslipidemia. Objective: The study was designed to identify the effect of P. guava leaf extract on hypertension in guinea pigs. And also to investigate lipid profiles, liver function tests and weight of mice fed a high fructose diet. Materials and Method: The study was conducted on twelve guinea pigs to measure the effect of P. guava leaf extract by using invasive and organ bath methods. Other experiment was done on 30 fructose fed Swiss albino mice to investigate the effect of P .guava leaf extracts on weight, lipid profiles and liver serum enzymes . Fructose fed mice for four weeks were treated with different doses of extracts for additional three weeks while maintaining high fructose diet. Then weight of mice were measured three times during the experiment. And also the end of seventh week, animals were sacrificed and lipid profile (TC, TG, HDL-C and LDL-C ) and serum enzymes (AST, ALT and ALP) were analyzed by using chemical analyzer. The result was statically analyzed by using paired t-test independent student t test, one –way ANOVA and mean comparison, Microsoft excel. Result: The ethanol extract of P. guava leaf showed a significant ability to relax isolated aortas of guinea pigs in ex vivo experiments, after induction ofaortic muscle contraction by high potassium concentrations. P. guava leaf extracts also lowered the systolic and diastolic blood pressure of live guinea pigs in in vivo experiments. P .guava leaf extracts also significantly reduced the weight , improved lipid profiles and reduces liver serum enzymes in fructose-fed mice. Conclusion: The effect of P .guava leaf extract in reduction of hypertension, improvement of lipid profiles and possible protection against liver damage may be due to numerous benefits of phytochemicals.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Psidium guava, hypertension, blood pressure, lipid profile, guinea pigs, mice, dyslipidemia, serum enzymes, hepatoprotective, effect |
| Subjects: | Q Science > Q Science (General) S Agriculture > S Agriculture (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 25 Sep 2018 12:02 |
| Last Modified: | 25 Sep 2018 12:02 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/5721 |
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