Yigezu, Agerie (2014) SeroPrevalence of Hepatitis C Virus among HIV Infected Individuals and Comparison of Basic Laboratory and Clinical Parameters at ART clinics of Tikur Anbessa Specialized and Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Hepatitis C virus (HCV) infection is common in Human Immunodeficiency virus (HIV)-infected persons as both may have common mode of transmission. HIV and HCV co infection is a major global health concern. However, data on co-infection are limited in Ethiopia. Objective: The aim of this study was to determine sero-prevalence of hepatitis C virus among HIV infected individuals and comparison of basic laboratory and clinical parameters at ART clinics of Tikur Anbessa Specialized and Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Methods: A hospital based cross-sectional survey was carried out on HIV follow up attendees from July to November, 2013. An interviewer-administered questionnaire was used to collect data on demographic information, and risk factors associated with HCV infection and clinical, common hematological ,CD4 T cell count and LFT profiles were also collected using pretested structured checklists .AntiHCV antibodies was detected using enzyme immunoassay test kit (EIA-ANTI-HCV) according to manufacturer instruction. We used Epi–Info version 3.5.1 and SPSS version 21 statistical package for data entry and analysis. Results: All consecutive attendants recruited in the study (n=282), were HIV follow up cases. There were more females 207(73.4%) than males 75 (26.6%). The sero-prevalence of HCV was 5.3% (15/282, 95% CI= 3% - 8%). There was no significant difference in HCV seroprevalence with age and sex (p > 0.05). Hospital admission was found to be a possible risk factor for HCV infection (p<0.05). Majority of HCV infected patients were functionally active and had normal BMI. About 3.7 % of HCV infected subjects were belongs to WHO stage II. Mean WBC, Hgb, HCT, Plateletes,Lymphocyte, Neutrophile, CD4 T cells count , ALT, AST and ALP for HIV/HCV coinfected and only HIV infected persons found to be {9,09 ± 10.05*,13.3 ±1.6, 40.7 ± 4.8, 287.7 ± 72.1*, 2.1 ± 1.1*, 3. 6 ± 1.9*,415.5 ± 219.2, 29.47 ± 30.8, 40.07 ± 39.4, 273.2 ± 120.8}, {7.38 ± 9.039*,14.3 ± 5.149, 42.07 ± 4.94, 291.9 ± 103.56*, 2.43 ± 0.96*, 3.7 ± 1.8*, 451.29 ± 243.2, 25.4 ± 14.6, 26.1 ± 12.1, 254.58 ± 96.82}, respectively. About 5 % of co infected patients are taking ART. There is statistically significant difference in mean AST level for HCV co infected and HIV monoinfected groups (p < 0.001). Conclusion: The seroprevalence of HCV infection in HIV positive cases is found to be moderately high. Hence it is appropriate to screen all HIV patients for HCV. It is also appropriate to give health education concerning transmission, risk factors and prevention of HCV infection. * should be multiplied with 103
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | HIV, HCV, Co-infection, ALT, AST, ALP |
| Subjects: | Q Science > Q Science (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 27 Jun 2018 11:57 |
| Last Modified: | 27 Jun 2018 11:57 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6027 |
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