Meressa, Guesh (2014) The Acute Effects of Khat Ingestion on Pulmonary Function and Oxygen Saturation in Human. Masters thesis, Addis Ababa University.
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PDF (The Acute Effects of Khat Ingestion on Pulmonary Function and Oxygen Saturation in Human)
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Abstract
Background: Khat (Catha edulis Forsk) is a plant mostly grown and used in east African countries and the Arabian Peninsula since ancient time with a progressive increase of use in the recent time. It is becoming an important concern worldwide and the khat producing countries in particular for its stimulant effect. Objectives: This study was designed to assess the acute effect of khat ingestion on pulmonary function and arterial hemoglobin oxygen saturation in human. Methodology: This experimental study was done in 20 study participants. Data gathering tools included Biopac data acquisition systems for determination of FVC, FEV1, FEV2 FEV1%, MVV, VT, and NRR. Pulse Oxymetry was also used to measure oxygen hemoglobin saturation. Then, data obtained were analyzed using quantitative and qualitative techniques. Results: This study showed statistically significant increase (P<0.05) in the mean values of pulmonary function parameters of FVC, FEV1, FEV2, FEV% and MVV (P<0.001). However, there were no statistically significant changes in TV (0.065), NRR (0.543), and Sao2 (P<0.398). Conclusion: The increase in FVC, FEV1, FEV2, FEV1%, and MVV after khat chewing shows an increase in respiratory effort and/or an increase in response of the respiratory system to the respiratory effort. There were no significant changes in the ventilation rate, tidal volume, and arterial Oxygen hemoglobin saturation at rest following khat ingestion. Recommendation: Further studies are needed to draw more systematic scientific conclusions on the acute effects of khat in respiratory system. Multidisciplinary research studies may be needed to support more comprehensive evaluation of the observed effect at molecular level. The long term effects of khat on the stability of the alveoli, removal of inhaled particles, may be of important direction and concern of future research on the pulmonary function.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 03 Jul 2018 08:54 |
| Last Modified: | 03 Jul 2018 08:54 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6303 |
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