Dereje, Melka (2015) Assessment of Sleep Disorder Pattern of Patients with Parkinson Disease Attending Neurology Referral Clinic in TIKUR Anbessa Specialized and Zewditu Memorial Hospitals, Addis Ababa, Ethiopia: A Cross-Sectional Point Prevalence Study. Other thesis, Addis Ababa University.
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Abstract
Background: Parkinson’s disease (PD) is progressive neurodegenerative disorder characterized by abnormal motor symptoms such as bradykinesia, tremor, rigidity, and postural instability. However, the nonmotor symptoms (NMS) of PD, including cognitive impairment, depression, psychosis,& sleep disorders are also important and could have greater significance for disability, decreased quality of life, and reduced lifespan of the patients. Sleep-related problems specific to PD may occur early and even predate the diagnosis of the disease but are generally more frequent and more severe in patients with advanced PD. Little is known about sleep disorder pattern in people with Parkinson’s disease (PD) in Ethiopia and Africa. Objective: To assess the prevalence of sleep disorder pattern and their associated predictors in PD patients in Tikur Anbessa Specialized Hospital and Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Methods: A cross-sectional follow up study was used to collect data on all 155 study respondents who visited the clinic over the four months of the study period. Data was collected using tool (standardized questionnaire) by trained neurology nurses and neurology residents. All the respondents were identified using a selection a criterion satisfying the required ethical clearance procedure was used including securing verbal consent before data collection. Then collected data was cleaned and analyzed using SPSS version 20 to determine the magnitude/prevalence of sleep disorder and regression with p-value to determine the associated factors that explained the dependent variable. Included: All PD patients on follow up or diagnosed during a study period fulfilling the UK Brain Bank Criteria for idiopathic PD. Exclusion criteria: included the following: PD Patients with cognitive impairment who was unable to respond for the PDSS-2, PD Patients who didn’t have willingness to give informed consent and PD patients out of the study period.The data included 155 PD patients. We used the PDSS-2 to collect sleep disorder Symptoms. Data were entered and analyzed by a computer software SPSS version 20. First bivariate analysis was done to identify those factors that determine the dependent variable then multivariate analysis and Chi-Squares were used to determine those factors that determine the their possible associated predicting factors. P values<0.05 at confidence interval 95% were considered significant. Results: Majoirity, 127 (81.9%) of the respondents were male. Almost all 140(90.6%) of the respondents getting up at night to pass urine at least one day per week and followed by 104(67%) who were unable to turn around while in bed in at least one day in a week. Patients reported problems on all items of sleep disorder, the least score being 4 and maximum score being 39 which indicates there was no patient without sleep disturbance pattern. The most striking point was 13.5% of patient had a score of more than 30. Over all 30.1% of patient slept well for less than 3 days per week. About one third of Parkinson disease (PD) patients (35%) Wake up early in the morning with painful posturing of limbs. Patient’s age, marital status, employment status, PD symptom duration, historical reportable sleep disturbance and disease severity were related to advanced sleep disturbance with p- value of 0.04, 0.02, 0.00, 0.01, 0.002 and 0.001 respectively. Conclusions: Sleep disturbance symptoms on PD patients are prevalent in our study. When disaggregated, it increase with age ,higher disease severity, disease duration, being un married and un employed and presence of reportable previous sleep disturbance before PD symptoms. Considering the prominence of sleep disturbance in PD patients in this study, there warrants increase clinical awareness and efficacious therapies by neurology department on internal medicine and neurology residents as part of teaching and learning activities.
| Item Type: | Thesis (Other) |
|---|---|
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 10 Jul 2018 14:26 |
| Last Modified: | 10 Jul 2018 14:26 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6919 |
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