Gizachew, Mekonen (2015) The Relationship between Perinatal Factors and Thyroid Stimulating Hormone (TSH) Level in Newborns Cord Blood in Tikur Anbessa Hospital. Masters thesis, Addis Ababa University.
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Abstract
Background: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency present at birth. Untreated, CH has deleterious effects on growth and development of infants. Thyroid stimulating hormone (TSH) is used as a compulsory newborn screening assay to evaluate for congenital hypothyroidism. Objective: The main objective of this study was to assess the relationship between perinatal factors and TSH level in the newborns cord blood. Materials and Methods: A cross sectional study was conducted in Tikur Anbessa Hospital from November 26, 2014 - January 26, 2015. Perinatal factors such as body birth weight (BBW), gestational age, newborns sex, maternal age, parity, pregnancy induced hypertension, gestational diabets and 1st & 5th minute apgar score were documented. Five ml of blood was drawn from umbilical cord, centrifuged and analyzed for thyroid profile using enzyme-linked immunosorbent assay (ELISA). The perinatal factors were compared with cord blood TSH level. Differences were considered statistically significant when p<0.05. Results: Eighty nine newborns were enrolled in the study. Of these, 44(49.4%) were males and 45(50.6%) were females. The median TSH level of the study newborns were 9.038µIU/ml, whereas the mean T4 and T3 level of these newborns were 18.53±6.13µg/dl and 1.01±0.375ng/ml, respectively. Among the perinatal factors, mode of delivery had statistically significant association with cord blood TSH concentration (p<0.05). Other factors such as BBW, gestational age, maternal age, gestational diabetes, pregnancy induced hypertension, parity, newborns sex, 1st & 5th minute apgar score didn`t have statistically significant relationship with cord TSH level. Newborns who were delivered by elective cesarean section (C/S) had lower TSH level than newborns who were delivered by emergency C/S, spontaneous vaginal delivery (SVD) and instrumental delivery. Conclusion: These results suggest that the only factor that can affect cord blood TSH level was mode of delivery. Newborns with elective C/S had lower TSH level and T4 level in cord blood. From this we can deduce that labor increase TSH and T4 concentration at birth. So, mode of delivery should be taken in to account while interpreting TSH and T4 levels to detect CH.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | congenital hypothyroidism, umbilical cord blood, thyroid stimulating hormone |
| Subjects: | Q Science > QP Physiology R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 29 Oct 2018 12:52 |
| Last Modified: | 29 Oct 2018 12:52 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7077 |
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