Gedamu, Melak (2015) Assessment of Adherence and Treatment Outcome among Epileptic Patients on Follow-up at Amanuel Specialized Mental Hospital. Masters thesis, Addis Ababa University.
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Abstract
Anti-epileptic drugs (AEDs) are the primary therapeutic modes for epileptic patients and have been demonstrated to control seizure, which decreases morbidity and mortality associated with epilepsy. There is a paucity of data on treatment outcome among epileptic patients in resource poor settings. The aim of this study was therefore to assess adherence and treatment outcome among epileptic patients. A cross-sectional study was conducted among epileptic patients on follow-up at Amanuel Specialized Mental Hospital. Patients who had follow up for at least two years were recruited in the study to evaluate adherence and treatment outcome through medical records review and patient interview. Factors affecting adherence and seizure control were determined using regression analysis. From a total of 397 patients 61% were males. The common type of seizure diagnosed was generalized tonic clonic seizure (76.1%). Monotherapy was commonly (74.8%) used in the management of seizure, among which phenobarbitone was the most commonly utilized (60.5%) single anticonvulsant drug. About 70% patients were adherent to their treatment and only 38.6% of the patients were seizure free for at least two years. Seizure free period and year of follow up were found to have significant association with adherence. Number of drugs, side effect burden, adherence and educational levels were found to have a significant association with seizurecontrol status. The findings collectively indicate that health care providers should focus on adherence, treatment modality and side effect burden to control seizure. In addition, for those patients who were seizures free for at least two years, there must be a consideration of clinical assessment to withdraw AED treatment.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | adherence, anti-epileptic drugs, epilepsy, treatment outcome |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 29 Oct 2018 07:39 |
| Last Modified: | 29 Oct 2018 07:39 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7095 |
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