Guracha, Eshetu (2016) Rate of False Deferral and False Pass of Prospective Blood Donors Screened by Copper Sulphate Gravimetric Method at Hossana Blood Bank, Hossana, South Ethiopia. Masters thesis, Addis Ababa University.
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PDF (Rate of False Deferral and False Pass of Prospective Blood Donors Screened by Copper Sulphate Gravimetric Method at Hossana Blood Bank, Hossana, South Ethiopia.)
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Abstract
Background: The primary responsibility of a blood transfusion service (BTS) is to provide a safe, sufficient and timely supply of blood and blood products so as to ensure that blood donation causes no harm to the donor. The Copper Sulphate (CuSO4) screening test has been found to erroneously include anemic people and exclude eligible people and its performance is not well studied in poor settings like Ethiopia. Objectives: To determine the rate of false deferral and false pass of prospective blood donors screened by the copper sulphate gravimetric test from April to June 2016 at Hossana blood bank, Ethiopia.. Methods: A cross- sectional study was carried out from April to June 2016 in Hossana blood bank. Blood sample from 422 voluntary donors were collected and analyzed by CuSo4 gravimetric test and automated hematology analyzer (Cell-dyn 1800). The data was entered in Epi-Data 3.1 and analyzed by SPSS 20 and interpreted accordingly. P value less than 0.05 was considered as statistically significant. Agreement between the two methods was determined using the Kappa coefficient. Result: The overall deferra1 rate was 20.1% by the reference method and varies by blood collection site for the copper sulphate method (15.4% and 16.8% using capillary and whole blood, respectively). False pass rates were 9.2% and 7.6% and false fail rates were 4.5% and 4.3% using capillary and venous blood samples, respectively. The CuSo4 method using capillary blood sample had sensitivity of 94.4%, specificity 54.1%, PPV 89.1% and NPV 70.8%, while using venous blood sample it gave sensitivity of 94.7%, specificity 62.4%, PPV 90.9% and NPV 74.6%. The CuSo4 method had moderate with Kappa value of 0.53, (95% CI, 0.425-0.625, P<0.01) and substantial (Kappa value of 0.61, 95% CI (0.507 to 0.698), (P<0.01.) level of agreement with the reference method using capillary and venous blood samples, respectively. Conclusion: The high rate of false pass warrants the search for an alternative simple method to replace the old copper sulphate method. Until replaced, CuSO4 method which moderately agrees with the reference method can be retained as a primary screening tool by applying strict quality control method.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 29 Oct 2018 13:44 |
| Last Modified: | 29 Oct 2018 13:44 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7102 |
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