Tesfa, Mulugeta (2012) Assessment of Determinants of Adherence to Antiretroviral Therapy among People Living with HIV/AIDS at Debre Markos Referral Hospital. Masters thesis, Addis Ababa University.
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Abstract
Background: At the end of 2009, there were about 33.3 million [31.4 million –35.3 million] people living with HIV globally. About one million people live with HIV in Ethiopia. More than five million people are now receiving HIV treatment. In Ethiopia 1.1million people live with HIV at end of 2009. Total number of PLWHA on treatment as of March 2010 was 186,607 with a coverage of 64% of those in need. The advent of highly active antiretroviral treatment (HAART) has dramatically improved the prognosis for HIVpositive patients. The efficiency of antiretroviral therapy depends on a near perfect level of patients’ adherence. Antiretroviral treatment adherence levels of > 95% optimize patients` outcomes and minimize antiretroviral drug resistance. Objectives : The objective of this study was to assess the level of adherence and its determinants for antiretroviral treatment among people living with HIV/AIDS on highly active antiretroviral therapy(HAART) at Debre Markos Referral Hospital in East Gojjam Zone. Methods: A cross sectional survey design using both quantitative and qualitative methods was used to conduct this study. Systematic random sampling technique was used to select participants for the quantitative assessment. A total of 528 people living with HIV/AIDS and treated with highly active antiretroviral drugs were involved to examine sets of variables using an interview method and card review to address some variables. Result : Out of the 528 participants, 312(59.1%) were females. The mean age was 36 + 9.5 years and ranged from 18 to 75 years. The adherence level based on seven days recall self-reported dose adherence was 94.5%. Independent predictors of HAART adherence reported in this study included: residence i.e. the odds of being adherent was four (AOR: 4.348; 95% CI: 1.725,10.960; p =0.002) times more likely among urban patients than rural patients. The odds of being adherent was seven (AOR: 6.967; 95%CI: 1.03,37.251; p=0.023) times more likely among those satisfied with their better health condition than those who did not satisfied. Those who had child under their care(AOR:0.227; 95% CI: 0.103, 0.742; p=0.011) times less likely to be adherent than those who did not have child under care. The odds of being adherent was (AOR=0.325; 95%; CI=0.11,0.951) times less likely among substance and alcohol users than non-users. This study also showed that being away from home, busy with other things, forgetting, lack of transportation were common causes for missing of doses to the study participants. Conclusion and Recommendation: The result of this study showed that living in rural areas and absence of satisfaction obtained from health change after starting of antiretroviraltreatment, presence of children under care and substance use were negative predictors for adherence. Therefore, emphasis should be given on these factors to improve adherence.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 27 Nov 2018 08:24 |
| Last Modified: | 27 Nov 2018 08:24 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7647 |
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