Siraj, Munira (2016) Demographic Pattern, Risk Factors, Clinical and Microbiological Characteristics of Fungal and Bacterial Keratitis in Menilik II Memorial Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background:-Microbial keratitis is an infection of the cornea that is associated with a risk of permanent visual impairment. It can be caused by bacteria, virus, fungi, protozoa and other parasites. The incidence of corneal blindness caused by microbial keratitis in the developing world is far higher than that in the developed world. Objective:-the aim of this study was to determine the demographic pattern, risk factors, clinical and microbiological characteristics of fungal and bacterial keratitis in Menilik II memorial hospital, Addis Ababa, Ethiopia. Methods and materials: - a cross sectional study was conducted at Menilik II memorial hospital, a convenient sampling technique was used from January to September 2016. Sixty patients who were suspected to have microbial keratitis and fulfilled the requirements were included in the study. After taking a detailed history, corneal scrapping was taken by the ophthalmologist after installation of preservative free anaesthesia. Scrapping was smeared on two slides for preparation of gram stain and10% KOH wet mount and further scrapping was inoculated in to 0.5ml BHI broth media. Then from the broth media the sample were inoculated on bacterial and fungal solid media in the main laboratory as soon as possible. On each sample Comprehensive microbiologic studies were performed. Data were entered in to SPSS version 20 software and analysis was done. Result 60 patients of presumed microbial keratitis were included in this study. Of sixty cases of microbial keratitis investigated, fungi and bacteria were recovered from 29and 18 patients giving fungal and bacterial keratitis prevalence of 48.3 % and 30% respectively Potential risk factors identified were in 80% of cases. Corneal trauma was the main risk factor (55%). The most common Fungi pathogen isolated were Aspergillus spp (41.4%) followed by Fusarium spp (24.1%). Coagulase negative staphylococci and staphylococci aureus were the common bacterial agent accounting 44.4%and 22.2% respectively from the total bacterial isolates. Conclusion Corneal trauma was the major predisposing factor for microbial keratitis. Aspergeilius and coagulase negative Staphylococcui were the most common isolates.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 26 Nov 2018 12:40 |
| Last Modified: | 26 Nov 2018 12:40 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7686 |
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